Thomas W. Kensler, PhD

Thomas W. Kensler, PhD

University of Pittsburgh
Pittsburgh, PA, USA

Dr. Thomas Kensler received his Ph.D. in toxicology from M.I.T. Following postdoctoral fellowships at the McArdle Laboratory for Cancer Research, University of Wisconsin and at the National Cancer Institute in Bethesda, MD, he joined the faculty of the Johns Hopkins Bloomberg School of Public Health, Baltimore MD in 1980. In 1992, he was promoted to the rank of Professor. In 2010, he moved his primary appointment to the University of Pittsburgh and hold appointments as Professor in the Department of Pharmacology & Chemical Biology and the Department of Environmental and Occupational Health. Dr. Kensler also holds several Visiting Professorships in China. His research interests are in environmental carcinogenesis and cancer prevention. His work demonstrates that activation of KEAP1-NRF2-signaling pathway is a key adaptive response to environmental and endogenous stresses and can be effectively targeted by thiol-reactive small molecules. He has led several clinical trials of inducers of the Nrf2 pathway in the Qidong region of China. Recent trials have focused on interventions with broccoli sprout-derived beverages (rich in sulforaphane) as modulators of aflatoxin and air pollutant metabolism and DNA damage. Dr. Kensler is a past chairman of the NIH Chemo/Dietary Study Section and is currently a Senior Editor for Cancer Prevention Research. He has received several honors including the 2007 AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention, the 2009 Society of Toxicology Translational Impact Award and the 2011 Friendship Award from the, People’s Republic of China, their highest award for foreign civilians. He is a 2016 Thomson Reuters Highly Cited Researcher and is currently a recipient of an NCI R35 Outstanding Investigator Award.