X. Shirley Liu, MD

X. Shirley Liu, MD

Dana-Farber Cancer Institute
Boston, MA

Dr. X. Shirley Liu is Professor of Statistics, Biostatistics and Computational Biology at Harvard University, and Director of the Center of Functional Cancer Epigenetics at Dana-Farber Cancer Institute. Her research focuses on algorithm development and integrative modeling of high throughput genomic data to understand the specificity and function of gene expression regulators in tumour development, progression, drug response and resistance. In computational biology, her laboratory developed widely used algorithms for transcription factor motif finding, ChIP-chip/seq, DNase-seq, and CRISPR screen data analysis. In epigenetics, she and colleagues identified the chromatin signature of embryonic pluripotency, and were the pioneers to use the dynamics of nucleosomes, histone marks, and DNase hypersensitivity to predict driving transcription factors and cis-elements in a biological process. In cancer biology, she and colleagues identified novel functions of ESR1, AR, FOXA1, EZH2, and NOTCH1 in various cancers, discovered many cancer-related long non-coding RNAs, and reported novel associations of tumor immunity with patient clinical features and outcome.