Fudan University, Shanghai, China
Dr. Lei obtained her Ph.D. in Biochemistry and Molecular Biology from Fudan University Shanghai Medical College (1999) and did her post-doctoral study with Dr. Hong Wu at UCLA. She is currently Cheung Kong Scholar Chair Professor and Senior PI, Fudan University Shanghai Cancer Center and Institute of Biomedical Sciences. Dr. Lei’s research focuses on cancer metabolism. Dr. Lei’s group has explored the sensing and utilization of different nutrients by cancer cells, identifying key enzymes implicated in oncogenic alterations of metabolism, which provide the insight into the mechanism underlying metabolic alterations during cancer initiation and progression. She has been honored with many awards such as National Science Fund for Distinguished Young Scholars and China Female Young Scientist.
- Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce |á-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth. Nature Commun. 2018; 9: 4429. doi: 10.1038/s41467-018-06841-724
- Wang YP*，Wang J，Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016，64, 673–687 Highlights：Cancer discovery
- Gao X#, Lin SH#，Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D， Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960
- Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013；51, 506–518
- Lv L, Li D, Zhao D, Lin R, Chu Y，Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011；42, 719-730
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